个人简介

林燕飞，博士，讲师，中共党员。2018年9月毕业于浙江大学药物化学专业，获得博士学位。工作以来，主持浙江省基础公益研究计划项目1项，市厅级科研项目1项，横向课题2项，校教改项目1项，博士科研启动项目1项。目前主要从事功能化荧光分子探针的精准构筑及其应用研究、用于实时监控与精准递送的可激活型荧光前药研究、以及药物化学生物学驱动的活性小分子发现、优化与治疗应用等研究。近5年在Angew. Chem. Int. Ed., Chem. Eng. J., Int. J. Biol. Macromol., Talanta, Chem. Commun., Sens. Actuators B Chem., Food Chem., J. Agric. Food Chem., Ind. Crops Prod., Microchem. J., Dyes Pigm.等期刊发表论文三十余篇，其中以通讯作者身份发表论文二十余篇。

主讲课程

本科生课程：《药物化学》，《有机化学》，《有机化学实验》，《制药项目化实验》等

研究生课程：《药物制剂前沿技术》，《天然药物化学》等

研究方向

功能化荧光分子探针的精准构筑及其在生物医学、食品安全与环境监测中的应用；

用于实时监控与精准递送的可激活型荧光前药研究；

药物化学生物学驱动的活性小分子发现、优化与靶向治疗应用；

主持项目

浙江省基础公益研究计划项目，具有大 Stokes 位移和线粒体靶向的近红外荧光探针用于过氧亚硝酸盐生物传感及其在肿瘤和神经退行性疾病诊治中的应用，LTGC23B060001，2023.01-2025.12

嘉兴市科技项目，具有抗衰老活性的天麻素衍生物的合成、构效关系及作用机制研究，2021AD10017，2021.01-2023.12.

横向课题，药物中间体绿色合成工艺研究，2026.03-2029.03

代表论文（近五年）

(1)Kan, Z., Xu, L., Wei, D., Wang, F*., Liu, L., Lin, Y*., Zhao, G., Xie, L., Zhang, L*., & Du, G. (2026). Using high-performance chitosan based thermosetting resin to construct flame-retardant wood laminated composites through "face-core" synergy. European Polymer Journal, 248, 114614.

(2)Mei, X., Long, Q., Lu, A., Wang, F*., Zhu, X., Lin, Y*., Chai, X., Zhang, L*., Liu, L*., & Du, G. (2026). Preparation of fluorescent wood based on a novel flavonoid skeleton fluorescent probe for naked eye detection of dichloromethane, trichloromethane, and carbon tetrachloride. Journal of Environmental Chemical Engineering, 14(1), 120537.

(3)Zhou, M., Liu, C., Lin, Y*., Bai, T., Ye, T., Qian, Z., Li, L., Guo, L., Liu, H*., & Wang, J*. (2025). Novel near-infrared fluorescent probe with large stokes shift for detection of cysteine in food samples and living cells. Food Chemistry, 464, 141755.

(4)Li, Y., Zhong, L., Ye, T., Xu, M., Zhu, T., Lin, Y*., Guo, L., & Wang, J*. (2025). Water-soluble near-infrared colorimetric and ratiometric fluorescent probe for bisulfite/sulfite in food samples, plant roots and living cells. Microchemical Journal, 218, 115707.

(5)Sun, Y., Lin, Y., Zhou, Q*., Han, Y., Mao, M., Guo, L., Liu, H., & Wang, J*.  (2025). Near-infrared fluorescent probe featuring a large Stokes shift for sensitive detection of NADH in diabetic models. Sensors and Actuators B: Chemical, 444, 138527.

(6)Mei, X., Bi, W., Yang, C., Long, Q., Lin, Y*., Ren, C., Zhang, L*., Du, G*., & Liu, L*. (2025). A cellulose-based fluorescent probe for the detection of hypochlorite and its applications in actual water samples and light emitting diode. International Journal of Biological Macromolecules, 305, 144485.

(7)Liu, L., He, J., Bi, W., Xiao, Y., Lin, Y*., Ren, C., Chai, X*., Lei, H., Du, G., & Zhang, L*. (2025). High sensitivity fluorescent probe based on aminated cellulose for detecting SO2 derivatives and its application in food analysis. Industrial Crops and Products, 235, 121748.

(8)Bi, W., Ren, C., Xiao, Y., Wang, F*., Long, Q., Lin, Y*., Yang, X., Liu, L*., Zhang, L*., & Du, G. (2025). A cellulose-based near-infrared fluorescent probe for ratiometric imaging and visual monitoring of ClO- in water via smartphone. Environmental Research, 286, 122760.

(9)Zhong, L., Niu, H., Lin, Y*., Ye, T., Zheng, S., Chen, K*., Li, L., Guo, L., & Wang, J*. (2024). Near-infrared multi-functional aggregation-induced emission fluorescent probe for detection of viscosity and peroxynitrite and its imaging application. Microchemical Journal, 206, 111540.

(10)Liu, C., Lin, Y*., Chen, Z., Ye, T., Qian, Z., Li, L., Guo, L., Liu, H*., & Wang, J*. (2024). Novel colorimetric and near-infrared ratiometric fluorescent probe for sensing cysteine in food samples, plants, and living cells. Journal of Agricultural and Food Chemistry, 72(42), 23580-23591.

(11)An, S., Lin, Y*., Ye, T., Bai, T., He, D., Guo, L., Qian, Z., Li, L., Liu, H*., & Wang, J*. (2024). An extra-large Stokes shift near-infrared fluorescent probe for specific detection and imaging of cysteine. Talanta, 267, 125247.

(12)Zhao, M., Lai, W., Li, B., Bai, T., Liu, C., Lin, Y., An, S., Guo, L., Li, L., Wang, J*., & Zhang, F*. (2024). NIR-II fluorescence sensor based on steric hindrance regulated molecular packing for in vivo epilepsy visualization. Angewandte Chemie International Edition, 63(26), e202403968.

(13)Zhou, M., Lin, Y., Bai, T*., Ye, T., Zeng, Y., Li, L., Qian, Z., Guo, L*., Liu, H*., & Wang, J*. (2024). An activated near-infrared fluorescent probe with large Stokes shift for discrimination of bio-thiols. Sensors and Actuators B: Chemical, 414, 135994.

(14)Sun, Y., Mao, Y., Bai, T., Ye, T., Lin, Y., Wang, F., Li, L., Guo, L*., Liu, H*., & Wang, J*. (2024). An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH. Chemical Communications, 60(46), 5932–5935.

(15)Zeng, H., Yuan, X., Yang, X., Liu, L., Lin, Y*., Xie, L., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2024). Synthesis and application of hypochlorite ratiometric fluorescence probe based on cellulose. International Journal of Biological Macromolecules, 260, 129660.

(16)Mei, X., Yuan, X., Yang, Y., Liu, L., Lin, Y*., Xie, L., Chai, X*., Xu, K., Du, G., & Zhang, L*. (2024). Quantitative detection of L-cysteine with a ratiometric probe combined with smartphone imaging and fluorescent test strips. Journal of Molecular Structure, 1312, 138486.

(17)Niu, H., Ye, T*., Yao, L., Lin, Y., Chen, K., Zeng, Y., Li, L., Guo, L., & Wang, J*. (2024). A novel red-to-near-infrared AIE fluorescent probe for detection of Hg2+ with large Stokes shift in plant and living cells. Journal of Hazardous Materials, 475, 134914.

(18)Shi, S., Zhao, J., Yang, C., Liu, L., Zheng, H., Lin, Y*., Xie, L., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2024). Different solvents accompanied by different structures: Catalyst-free one step construction of highly branched polythioureas and its properties. European Polymer Journal, 211, 113032.

(19)Zhao, J., Yang, X., Yang, Y., Liu, L., Lin, Y*., Xie, L., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2024). Biomass polyamine-functionalized nanocellulose-loaded covalent organic framework to construct composite aerogels for highly efficient removal of Cr (VI) and methyl orange. Chemical Engineering Journal, 486, 150282.

(20)Wu, X., Yuan, X., Liang, E., Liu, L., Lin, Y*., Xie, L., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2024). A flavonol-labelled cellulose fluorescent probe combined with composite fluorescent film imaging and smartphone technology for the detection of Fe3+. International Journal of Biological Macromolecules, 259, 129373.

(21)Yuan, X., Qu, N., Xu, M., Liu, L., Lin, Y*., Xie, L., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2024). Chitosan-based fluorescent probe for the detection of Fe³⁺ in real water and food samples. International Journal of Biological Macromolecules, 265, 131111.

(22)Bi, W., Zhao, X., Yang, X., Yuan, X., Lin, Y*., Xu, K., Liu, L., Zeng, H., Du, G*., & Zhang, L*. (2024). Ratiometric fluorescent probe with AIE characteristics for hypochlorite detection and biological imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 323, 124904

(23)He, J., Yang, Y., Su, Y., Liu, L., Lin, Y*., Xie, L., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2024). A ratiometric fluorescent probe combined with smartphone technology based on cellulose for the detection of hypochlorous acid. International Journal of Biological Macromolecules, 280, 135943.

(24)Cao, H., Feng, W., Zeng, H., Jin, T., Lin, Y*., Xie, L., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2023). A innovative application of lactose cross-linked adhesive in plywood using hyperbranched network structure with high performance. Reactive and Functional Polymers, 191, 105698.

(25)Huang, Y., Jin, T., Zeng, H., Liu, L., Xu, K., Chai, X., Xie, L., Lin, Y*., Du, G. B*., & Zhang, L*. (2023). Development of novel sustainable hyperbranched polyester wood adhesives from glycerol and maleic anhydride by solvent free method. Industrial Crops and Products, 204, 117326.

(26)Shi, S., Jin, T., Liu, L., Xie, L., Lin, Y*., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2023). Novel hyperbranched resin for wood adhesive: Based on air oxidation and crosslinking copolymerization strategy. Polymer Testing, 126, 108154.

(27)Yuan, X., Yao, W., Ji, D., Liu, L., Lin, Y*., Zeng, H., Jin, T., Xu, K., Du, G*., & Zhang, L*. (2023). Synthesis of corn bract cellulose-based Au³⁺ fluorescent probe and its application in composite membranes. International Journal of Biological Macromolecules, 242, 124600.

(28)Yuan, X., Lv, J., Liu, L., Zhang, W., Lin, Y*., Xie, L., Chai, X., Xu, K., Du, G*., & Zhang, L*. (2023). The H2S detection based on the combined smartphone technology and cellulose composite film and its application in biological imaging. Journal of Molecular Structure, 1294, 136449.

(29)Yuan, X., Zhang, W., Liu, L., Lin, Y*., Yang, X., Xie, L., Chai, X., Xu, K., Du, G., & Zhang, L*. (2023). A chitosan-based fluorescent probe combined with smartphone technology for the detection of hypochlorite in pure water. Molecules, 28(17), 6316.

(30)Lai, W., Lin, Y*., Ye, T., Yu, Y., Zhou, H., Li, L., Mao, G*., & Wang, J*. (2023). A novel near-infrared ratiometric fluorescence probe for Hg²⁺ based on quinoline-fused rhodamine dye. Journal of Fluorescence, 33(4), 1413-1419.

(31)Pan, F., Li, H., Wang, X., Luo, L., Lin, Y*., Yu, Q., Xie, W*., & Zhang, L*. (2023). Synthesis of sulfur-containing benzo[b]pyrrolo[2,1-c][1,4]oxazine-3,9-diones: Blue light promoted radical cyclization process. RSC Advances, 13(20), 13911–13918.

(32)Mao, Y., Chen, W., Li, C., Miao, L., Lin, Y., Ling, F*., Chen, Z., & Yao, J*. (2023). Synthesis of 3,4,5-trisubstituted phenols via Rh(iii)-catalyzed alkenyl C–H activation assisted by phosphonium cations. Chemical Communications, 59(25), 3775–3778.

(33)Wu, J., Lin, Y*., Yu, Y., Li, Y., Ye, T., Zhou, H*., Li, L., & Wang, J*. (2022). A highly selective and sensitive fluorescence probe based on Rhodol for imaging of endogenous peroxynitrite in living cells. Dyes and Pigments, 206, 110597.

(34)Xiang, H., Ye, T*., Li, Y., Lin, Y., Liu, D., Zhou, H., Wang, J*., & Li, L*. (2022). A new ratiometric fluorescent probe based on BODIPY for highly selective detection of hydrogen sulfide. Molecules, 27(21), 7499.

(35)Diao, H., Liu, L., Wang, J., Lin, Y*., Zhao, X., Zeng, H., Shi, S., Gao, W., Yang, L., Du, G*., & Zhang, L*. (2022). Cupric halide-promoted stereoselective intramolecular cis-addition to construct (Z)-chloro(bromo)benzo[c,d]indoles. European Journal of Organic Chemistry, 2022(35), e202202811.

(36)An, S., Lin, Y., Wang, J*., Ye, T., Mao, Y., Zhang, J., Guo, L., Li, L., Qian, Z*., & Liu, H*. (2022). Near-infrared mitochondria-targeted fluorescent probe with a large Stokes shift for rapid and sensitive detection of cysteine/homocysteine and its bioimaging application. Sensors and Actuators B: Chemical, 369, 132799.

(37)Zhu, W., Zhang, Q., Bao, X., Lin, Y., Xu, G*., & Zhou, H*. (2022). Nucleophilic functionalizations of indole derivatives using the aromatic Pummerer reaction. Organic & Biomolecular Chemistry, 20(19), 3955–3959.

获奖情况

指导学生获得第11届浙江省大学生化学知识竞赛一等奖1项、三等奖1项（2019年）

指导学生获得第12届浙江省大学生化学知识竞赛三等奖（2021年）

指导学生获得第16届浙江省大学生化学知识竞赛三等奖（2025年）

联系方式

Email: [email protected]